冠心病病人血清超敏CRP与HDL-C的相关性分析

目的观察冠心病病人血中炎症参数超敏C-反应蛋白(Hs-CRP)、全血白细胞(WBC)及高密度脂蛋白胆固醇(HDL-C)的变化情况,揭示冠心病病人炎症变化过程.方法通过对24例正常人(NC),44例急性心肌梗死病人(AMI)、42例不稳定性心绞痛病人(UAP)及21例稳定性心绞痛病人(SAP)的超敏CRP、全血WBC及血清HDL-C三项指标的相关性分析,揭示炎症反应在冠心病发病过程中的表现.结果四组研究对象中Hs-CRP变化最明显,特别在AMI中升高最快;Hs-CRP与WBC呈明显的正相关性关系(P＜0.05),与HDL-C呈负相关关系(P＜0.01).结论在冠心病的发病过程中,存在有炎症反应过程.在疾病发病的某一时期,三个指标同时检测具有一致性.

Correlation Between Serum Hypersensitive CRP and HDL-C in Patients with CHD

Objective To observe the inflammatory parameters such as serum Hs-CRP (hypersensitive C-reactive protein) and white blood cells and their correlation with HDL-C (High density lipoprotein cholesterol) in patients with CHD (Coronary heart disease). Methods Serum Hs-CRP, HDL-C and WBC were measured in 21 control subjects and CHD patients including 44 AMI (Acute myocardial infarction), 42 UAP (Unstable angina pectoris) and 21 SAP (Stable angina pectoris). Results The Hs-CRP was higher in AMI patients than that in control subjects and in patients with SAP. Hs-CRP was negatively correlative with HDL-C, positive correlative with WBC. Conclusions An acute inflammatory process exists in the pathogenesis of CHD, and these 3 indexes might be consistent during certain stage of the disease.