| 白背叶提取物A的体外抗肿瘤活性研究 |
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| 引用本文： | 伦玉宁,郑作文,邹静.白背叶提取物A的体外抗肿瘤活性研究[J].时珍国医国药,2011,22(1):33-34. |
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| 作者姓名： | 伦玉宁 郑作文 邹静 |
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| 作者单位： | 广西中医学院,广西,南宁,530001 |
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| 基金项目： | 广西壮族自治区科学基金 |
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| 摘 要： | 目的观察白背叶提取物A对肿瘤细胞增殖的抑制作用。方法采用四唑盐比色试验(MTT法),以半数抑制浓度(IC50)为评价抗肿瘤活性强度的指标,分别对HL60人白血病细胞、Hela人宫颈癌细胞、A375人黑色素瘤细胞、MCF7人乳腺癌细胞4种常见的人恶性肿瘤细胞进行抗肿瘤活性的筛选。结果白背叶提取物A在浓度为10μg/ml时对HL60(P<0.05)、Hela(P<0.05)、A375(P<0.05)、MCF7(P<0.01)即有明显抑制作用(P<0.05或P<0.01),其IC50分别为29.64,30.36,36.65,42.81μg/ml。结论白背叶提取物A对以上4种肿瘤细胞的增殖均有抑制作用。
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| 关 键 词： | 白背叶提取物A 抗肿瘤 四唑盐比色试验 |
The anti - tumor Effect of Extract from Mallotus apelta Muell - Arg. in vitro. |
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| LUN Yu-ning,ZHENG Zuo-wen,ZOU Jing.The anti - tumor Effect of Extract from Mallotus apelta Muell - Arg. in vitro.[J].Lishizhen Medicine and Materia Medica Research,2011,22(1):33-34. |
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| Authors: | LUN Yu-ning ZHENG Zuo-wen ZOU Jing |
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| Institution: | (Guangxi Traditional Chinese Medical University,Nanning,530001,China) |
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| Abstract: | Objective To observe the inhibitory effect of extract A from Mallotus apelta Muell-Arg.on HL60,Hela,A375 and MCF7 tumor cell lines.Methods MTT assay was employed to test the anti-tumor effect of extract A in four kinds of malignant tumor cell lines,with IC50 applied to evaluate the degree of anti-tumor activity.Results Extract A at 10μg/ml,in a dose-dependent manner,inhibited the proliferation of HL60(P<0.05),Hela(P<0.05),A375(P<0.05),MCF7(P<0.01) cell lines effectively and the IC50 were 29.64,30.36,36.65,42.81μg/ml,respectively.Conclusion Mallotus apelta Muell-Arg.extract A can inhibit the proliferation of HL60,Hela,A375,MCF7 in vitro. |
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| Keywords: | Extract of Mallotus apelta Muell-Arg Anti-tumor MTT assay |
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