| 叶酸修饰碳纳米管的合成及其负载伊立替康的释放 |
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| 引用本文： | 周敏,彭政,廖双泉,李思东,李普旺.叶酸修饰碳纳米管的合成及其负载伊立替康的释放[J].医学教育探索,2012,25(4). |
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| 作者姓名： | 周敏 彭政 廖双泉 李思东 李普旺 |
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| 作者单位： | 1.海南大学材料与化工学院，海口 570228； 2.中国热带农业科学院农产品加工研究所，
广东 湛江 524001； 3.广东海洋大学理学院，广东 湛江 524088;1.海南大学材料与化工学院，海口 570228； 2.中国热带农业科学院农产品加工研究所，
广东 湛江 524001； 3.广东海洋大学理学院，广东 湛江 524089;1.海南大学材料与化工学院，海口 570228； 2.中国热带农业科学院农产品加工研究所，
广东 湛江 524001； 3.广东海洋大学理学院，广东 湛江 524090;1.海南大学材料与化工学院，海口 570228； 2.中国热带农业科学院农产品加工研究所，
广东 湛江 524001； 3.广东海洋大学理学院，广东 湛江 524091;1.海南大学材料与化工学院，海口 570228； 2.中国热带农业科学院农产品加工研究所，
广东 湛江 524001； 3.广东海洋大学理学院，广东 湛江 524092 |
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| 基金项目： | 海南省自然科学基金资助 (512106)；中国热带农业科学院院本级基本科研业务费专项资金资助 (1630032012051) |
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| 摘 要： | 以叶酸改性壳聚糖修饰的碳纳米管为药物载体，选用治疗结肠癌的抗癌药物伊立替康为模型药物，通过非共价包覆的方式制备具有靶向功能的碳纳米管基药物载体材料。采用FT-IR、UV和TGA等对各阶段产物进行表征，考察了纳米载体的载药率和药物体外释放性能。结果表明，模型药物成功加载到了功能化的碳纳米管上，其载药量达63.6%，包封率为85.92%。体外释放实验显示靶向功能化碳纳米管对伊立替康具有缓释作用，药物在37 ℃，pH=7.4的PBS缓冲溶液中能持续释放70 h以上。
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| 关 键 词： | 碳纳米管 壳聚糖 伊立替康 药物载体 药物缓释 |
Synthesis of Folate Decorated Carbon Nanotubes and
Its Irinotecan Release |
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| ZHOU Min,PENG Zheng,LIAO Shuang quan,LI Si dong and LI Pu wang.Synthesis of Folate Decorated Carbon Nanotubes and
Its Irinotecan Release[J].Researches in Medical Education,2012,25(4). |
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| Authors: | ZHOU Min PENG Zheng LIAO Shuang quan LI Si dong and LI Pu wang |
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| Institution: | 1. College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China;
2. Agricultural Product Processing Research Institute, CATAS, Zhanjiang 524001, Guangdong, China;
3. College of Science, Guangdong Ocean University, Zhanjiang 5240;1. College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China;
2. Agricultural Product Processing Research Institute, CATAS, Zhanjiang 524001, Guangdong, China;
3. College of Science, Guangdong Ocean University, Zhanjiang 5240;1. College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China;
2. Agricultural Product Processing Research Institute, CATAS, Zhanjiang 524001, Guangdong, China;
3. College of Science, Guangdong Ocean University, Zhanjiang 5240;1. College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China;
2. Agricultural Product Processing Research Institute, CATAS, Zhanjiang 524001, Guangdong, China;
3. College of Science, Guangdong Ocean University, Zhanjiang 5240;1. College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China;
2. Agricultural Product Processing Research Institute, CATAS, Zhanjiang 524001, Guangdong, China;
3. College of Science, Guangdong Ocean University, Zhanjiang 5240 |
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| Abstract: | Multi walled carbon nanotubes (MWCNTs) functionalized by folate (FA) conjugated chitosan (CS) were used as drug carrier. Irinotecan, as a model of anticancer drug, was non covalently encapsulated into (or onto) the functionalized carbon nanotubes. The obtained FA-CS MWCNTs nano materials were characterized with infrared spectra, UV-Vis spectroscopy and thermogravimetric ana lysis, and the drug loading efficiency and in vitro drug release profile was also studied. Results showed that the irinotecan was successfully loaded into functionalized carbon nanotubes, and the drug loading efficiency and encapsulated efficiency were 63.6% and 85.92%, respectively. The mass fraction of folate modified chitosan, carbon nanotubes and irinotecan in FA CS MWCNTs irinotecan was 18.6%, 44.3% and 38.9%, respectively. The release of irinotecan from carbon nanotubes at pH=7.4 showed a slow and sustained release over 70 h. |
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| Keywords: | carbon nanotubes chitosan irinotecan drug carrier drug release |
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