| 大豆多糖对S180荷瘤小鼠免疫调节作用的研究 |
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| 引用本文： | 张秀娟,孙向菊,严 松,李其成,刘思含,张 鑫. 大豆多糖对S180荷瘤小鼠免疫调节作用的研究[J]. 医学教育探索, 2012, 35(35): 420-422 |
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| 作者姓名： | 张秀娟 孙向菊 严 松 李其成 刘思含 张 鑫 |
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| 作者单位： | 1.哈尔滨商业大学生命科学与环境科学研究中心 生物安全评价研究所，黑龙江 哈尔滨 150076 2.国家教育部抗肿瘤天然药物教育部工程研究中心，黑龙江 哈尔滨 150076 3.哈尔滨商业大学 药学院，黑龙江 哈尔滨 150076 4.黑龙江省农业科学院 食品加工研究所，黑龙江 哈尔滨 150086 |
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| 基金项目： | 黑龙江省教育厅项目（12521133） |
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| 摘 要： | 目的 从免疫学角度探讨大豆多糖对荷瘤小鼠抗肿瘤作用的机制。方法 采用分光光度计测定大豆多糖对S180荷瘤小鼠巨噬细胞一氧化氮生成量的影响，利用酶标仪测定大豆多糖对S180荷瘤小鼠腹腔巨噬细胞吞噬功能的影响，定量溶血分光光度法检测B细胞功能。结果 与对照组比较，大豆多糖各组均能显著提高小鼠巨噬细胞的吞噬活性，同时能明显提高荷瘤小鼠巨噬细胞产生一氧化氮的能力，并能使体内B淋巴细胞数量增加而提高抗体生成量。结论 大豆多糖通过调节荷瘤小鼠免疫功能发挥抗肿瘤作用。
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| 关 键 词： | 大豆多糖；抗肿瘤；免疫调节 |
Immunomodulation of soybean polysaccharide on S180-bearing mice |
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| ZHANG Xiu-juan,SUN Xiang-ju,YAN Song,LI Qi-cheng,LIU Si-han,ZHANG Xin. Immunomodulation of soybean polysaccharide on S180-bearing mice[J]. Researches in Medical Education, 2012, 35(35): 420-422 |
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| Authors: | ZHANG Xiu-juan SUN Xiang-ju YAN Song LI Qi-cheng LIU Si-han ZHANG Xin |
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| Affiliation: | 1.Institute of Bio-safety Evaluation, Center of Research and Development on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China 2.Engineering Research of Natural Anticancer Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China 3.School of Pharmacy, Harbin University of Commerce, Harbin 150076, China 4.Food Processing Institute, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China |
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| Abstract: | Objective To study the antitumor effects of soybean polysaccharide (SPS) on S180- bearing mice and the mechanism from the point of immunological view. Methods The effect of SPS on the nitric oxide (NO) generation by macrophage in S180- bearing mice was detected by spectrophotometer; ELIASA was used to determine the effect of SPS on phagocytosis of macrophage; The function of B-lymphocytes was detected by quantitative haemolysis specteophotomeric method. Results Compared with the control group, SPS could significantly enhance the phagocytosis of macrophage and increase the NO generation of macrophage as well as the content of B-lymphocytes in S180- bearing mice, so as to increase the generation of antibodies. Conclusion SPS could play its antitumor role by regulating the immune function of mice. |
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| Keywords: | soybean polysaccharides (SPS) antitumor immunomodulation |
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