Hypoglycemic effect of Equisetum myriochaetum aerial parts on streptozotocin diabetic rats |
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Authors: | Andrade Cetto A Wiedenfeld H Revilla M C Sergio I A |
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Institution: | Biological Department, Science School, National University of México UNAM, DF., 04510 México, Mexico. |
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Abstract: | The hypoglycemic effect of water as well as butanolic extracts prepared from aerial parts of Equisetum myriochaetum (Equisetaceae) was examined in streptozotocin induced diabetic rats. A single oral administration of the water extract (WE) at doses of 7 and 13 mg/kg and of the butanol extract (BE) at doses of 8 and 16 mg/kg significantly (P<0.001) lowered the plasma glucose levels in diabetic rats after three hours of the administration. As a reference drug glibenclamide was used and showed, at a dose of 3 mg/kg, similar hypoglycemic effect like the tested extracts. Three kaempferol glucosides and one caffeoyl glucoside were isolated from the drug and were shown to be the main constituents in both extracts. |
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