黄连和小檗碱对实验性G6PD缺陷大鼠红细胞渗透脆性的影响

目的:了解黄连和小檗碱对G6PD缺陷大鼠红细胞渗透脆性的影响,藉以推断黄连和小檗碱是否存在药物性溶血作用。方法:将黄连煎液和小檗碱溶液通过体内、外给药途径,应用于G6PD缺陷大鼠,检测其红细胞渗透脆性的变化。结果:G6PD缺陷大鼠红细胞渗透脆性仅在超大剂量给药时才有所增高。黄连和小檗碱作用相似而后者略弱。结论:以红细胞渗透脆性为指标,一般黄连剂量尚不致引起溶血。黄连和小檗碱对正常红细胞有更大的安全性。

Influence of Huanglian and Berberine on the Erythrocytic Osmotic Fragilitas of Experimental Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Rats

Objective:To make clear the influence of Huanglian (Coptis chinensis) and berberine on the erythrocytic osmotic fragilitas of glucose-6-phosphate dehydrogenase(G6PD) deficiency in rats,so as to infer whether Huanglian and berberine have medicamentosus hemolysis effects.Method:Huanglian decoction and berberine solution are applied to the erythrocytes of G6PD deficiency in rats through external and oral administration and the erythrocytic osmotic fragilitas is measured.Result:Only at an excessively high dose can the medicines raise the erythrocytic osmotic fragilitas of G6PD deficiency in rats.Berberine and Huanglian have similar effects,but berberine is slightly weaker.Conclusion:Focus on the erythrocytic osmotic fragilitas,at a general dose,Huanglian can not cause hemolysis.Huanglian and berberine are of more safety to normal erythrocytes.