阿仑膦酸钠联合阿法骨化醇对糖皮质激素性骨质疏松的疗效

目的观察阿仑膦酸钠联合阿法骨化醇对糖皮质激素性骨质疏松（GIOP）的疗效。方法将54例GIOP患者分成A、B组。A组30例给予阿仑膦酸钠70mg，1次／周，阿法骨化醇0．25g，2次／d，碳酸钙750mg，2次／d；B组24例，在A组给药基础上减去阿仑膦酸钠。疗程共6个月。比较2组治疗前后骨密度（BMD）、血钙和血磷，同时比较2组疼痛评分。结果A组治疗后BMD、疼痛评分较治疗前均明显改善（P〈0．05）；B组无明显变化（P〉0．05）。A组上述结果与B组比较，差异均有统计学意义（P〈0．05）。2组治疗前后血钙、血磷变化均无统计学差异（P〉0．05）。结论阿仑膦酸钠与阿法骨化醇联合治疗GIOP疗效优于单用阿法骨化醇。

Combination therapy of alendronate and alfacalcidol on glucocorticoid-induced osteoporosis

Objective To investigate the clinical effect of combination therapy of alendronate and alfacalcidol on glucocorticoid-induced osteoporosis （GIOP）. Methods 54 patients with GIOP were randomly divided into 2 groups, group A （n = 30） were treated with alendronate（70 mg/week）, alfaeal cidol（0. 25 g,Bid）, calcium carbonate（750 mg, Bid） ;group B （n = 24） were treated with alfacalcidol （0. 25 g, Bid）, calcium carbonate（750 mg, Bid）. After the 6 months＇treatment, the changes of the bone mineral density （BMD） and spontaneous pain were measured, and serum levels of calcium and phosphorus were examined regularly too. Results After the treatment, the BMD at the were increased in group A, and the spontaneous pain were outstandingly mitigated（P〈0. 05）. But neither BMD nor the pain were significantly changed in group B （P〈0. 05）. And there were significant differences in the BMD and the pain between group A and B （P~0. 05） after the treatment. The changes of serum levels of calcium and phosphorus had no difference in two groups before and after treatment（P~0. 05）. Conclusions Compared with treated with calcium and alfacalcidol alone, combination with alendronate can effectively prevent the loss of bone mineral content induced by long-term use of glucocortieoid.