Relevance of plasma,glandular and urinary kallikrein in renal hypertrophy in streptozotocin-diabetic rats |
| |
Authors: | Mansour I. Sulaiman Saud F. Al-Fayz |
| |
Affiliation: | (1) Department of Pharmacology, King Abdulaziz University, Jeddah;(2) Department of Medicine, King Abdulaziz University, Jeddah |
| |
Abstract: | Summary The relevance of plasma, glandular and renal kallikrein as an intrarenal hemodynamic regulator, in renal hypertrophy, in 1–5 weeks streptozotocin diabetic rats has been investigated. The fasting plasma glandular kallikrein level significantly decreased with increasing duration of diabetes (p<0.05). Glandular kallikrein correlated negatively with kidney weight (r=0.76, p=0.05). The 24 hour urinary kallikrein excretion significantly increased with increasing duration of diabetes (p<0.05), but this level was not correlated with glucose level, nor with kidney weight. Aprotinin (a kallikrein inhibitor) injected (10×103 KIU/kg) twice daily for 2 weeks in diabetic rats, significantly decreased plasma glucose levels by 28%, 24 hour urinary kallikrein by 37% (p<0.05) and kidney weight by 6%. These results suggest that plasma, glandular and renal kallikrein did not play an important role in the renal hypertrophy observed in streptozotocin diabetic rats. |
| |
Keywords: | Aprotinin Diabetes Glandular kallikrein Kidney weight Urinary kallikrein |
本文献已被 SpringerLink 等数据库收录! |
|