氟哌噻吨美利曲辛联合常规药物治疗对伴焦虑抑郁情绪难治性哮喘患者的临床疗效

目的 探讨氟哌噻吨美利曲辛联合常规药物治疗伴焦虑抑郁情绪难治性哮喘患者的临床疗效.方法 对105例难治性哮喘患者采用综合医院焦虑抑郁量表（HAD）作筛查,伴发焦虑抑郁情绪患者随机分为实验组（39例）和对照组（36例）,两组均接受常规内科治疗,实验组同时联合氟哌噻吨美利曲辛治疗,采用哮喘控制测试（ACT）评分、HAD评分及肺功能评估治疗效果.结果 105例难治性哮喘患者中伴发焦虑抑郁情绪患者75人（71.42％）.经治疗,随焦虑抑郁程度的下降,哮喘控制程度也在改善.治疗后研究组HAD评分明显低于对照组（10.67±2.32）分vs （11.94±3.02）分,t=2.06,P＜0.05）];研究组ACT评分明显高于对照组（14.54±3.14）分vs （11.25±3.06）分,t=4.59,P＜0.01）];研究组FEV 1％ pre（FEV1/FVC）明显高于对照组（55.29± 5.72） vs （43.36±7.13）,t=8.02,P＜0.01）].结论 氟哌噻吨美利曲辛联合治疗可以改善患者的焦虑抑郁情绪,提高难治性哮喘的临床疗效,改善肺功能.

Clinical outcomes of flupenthixol melitracen combined with conventional drugs on refractory asthma with anxiety and/or depression

Objective To investigate the clinical outcomes of flupenthixol melitracen on refractory asthma with anxiety and/or depression.Methods 105 patients with refractory asthma,who were given asthma controlled test （ACT） and comprehensive hospital anxiety and depression scale （HAD）test,were randomly classified into control group and treatment group,the former used recommended classical drugs in the consensus,Salmeterol Xinafoate and Fluticasone Propionate and Montelukast;while the latter used above therapy combining flupentixol melitrace.HAD score,ACT score and pulmonary function were applied to assess therapeutic effect.Results In 105 cases of refractory asthma patients,75 patients were complicated with anxiety and/or depression,with prevalence of 71.42％.With the alleviation of anxiety and/or depression,the degree of asthma controlled was improved.After treatment,HAD score of the treatment group was lower that of control group（（10.67±2.32） scores vs （11.94±3.02） scores,t=2.06,P＜0.05）,ACT score in treatment group was much higher than that of control group（（14.54± 3.14） scores vs （11.25±3.06）scores,t=4.59,P＜0.01）,there were statistical significance in FEV1％ pre between two groups （（55.29±5.72） vs （43.36±7.13）,t=8.02,P＜0.01）.Conclusion Antidepressant treatment can alleviate anxiety and/or depression,improve the clinical curative effect of refractory asthma and help to improve lung function.