宫颈环形电切术治疗宫颈上皮内瘤变的临床疗效以及高危型人乳头瘤病毒检测在术后随访中的应用价值

目的探讨临床应用宫颈环形电切术(LEEP)治疗宫颈上皮内瘤变的临床效果以及高危型人乳头瘤病毒(HPV)检测对预后效果的评估价值。方法 2012年2月至2014年2月间收治的宫颈上皮内瘤变患者108例随机分为对照组和观察组,每组54例。对照组采用宫颈冷刀锥切术,观察组采用宫颈环形电切术,比较两组患者的临床治疗效果。同时,分别于术前与术后3个月开展高危型HPV检验,观察其对预后效果的评判价值。结果观察组患者的手术时间为(7.5±1.5)min,出血量为(8.2±3.1)ml,术后愈合时间为(28.0±3.2)d,均明显好于对照组,差异有统计学意义(P<0.05)。108例患者术后HPV阳性者的复发率与持续存在率均明显高于阴性者,差异有统计学意义(P<0.05)。结论宫颈环形电切术治疗宫颈上皮内瘤变具有较好的手术治疗效果,术后采用高危型HPV检测具有确切的预测效果。

Evaluation of clinical efficacy of loop electrosurgical excision procedure treatment of cervical intra- epithelial neoplasia and high-risk human papiilomavirns testing applications in the postoperative fol- low-up

Objective To evaluate the clinical application of cervical loop electrosurgical excision procedure （LEEP） treatment of cervical intraepithelial neoplasia, and assess the prognosis of high-risk hu- man papillomavirus （HPV） detection. Methods From February 2012 to February 2014, 108 patients with cervical intraepithelial neoplasia were randomly divided into the control group （54 cases） and the observa- tion group （54 cases）, patients in the control group accepting cervical cold knife conization, patients in the observation group accepting cervical loop electrosurgical excision procedure. Then clinical outcomes were conducted between the two groups. Preoperatively and postoperatively three months high-risk HPV test was carried out to judge the value of the observed indicators of prognosis. Results The patient＇s operative time was （7. 5 ±1.5） min, blood loss was （8. 2 ±3. 1 ） ml, postoperative healing time was （28. 0 ± 3. 2 ） d, were significantly better than the control group （ P 〈 0. 05 ）. 108 cases of postoperative recurrence rate of HPV-positive and persistence were significantly higher than negative ones （P 〈 0.05 ）. Conclusion The clinical application of cervical loop electrosurgical excision procedure to treat cervical intraepithelial neopla- sia can achieve better surgical treatment, and the use of high-risk HPV testing in the postoperative follow-up has good predictive effect.