胎盘多肽注射液辅助治疗中晚期口腔癌的疗效观察

目的探讨胎盘多肽注射液联合化疗治疗中晚期口腔癌的有效性和安全性。方法选取2010年10月至2012年8月间行化疗的中晚期口腔癌患者128例,随机分为胎盘多肽联合化疗的治疗组(65例)和单纯化疗的对照组(63例)。治疗组患者于化疗前1d开始注射胎盘多肽8ml,连用7d,28d为1个周期,共用4个周期。评价治疗效果、患者全身状态和药物毒性等。结果治疗组和对照组患者的有效率分别为55.4%和53.9%,差异无统计学意义(P>0.05)。治疗组患者化疗后QOL、KPS评分高于对照组,差异有统计学意义(P<0.05)。治疗组患者化疗后白细胞下降程度低于对照组,恶心呕吐、口腔黏膜炎发生率也明显低于对照组,差异有统计学意义(P<0.05)。两组患者其他外周血象指标及腹泻、脱发、肝功能异常等不良反应发生率相似,差异无统计学意义(P>0.05)。结论中晚期口腔癌患者化疗期间,联合应用胎盘多肽注射液能够辅助治疗肿瘤,并具有较好的安全性,值得进一步在临床推广应用。

Clinical effect observation of placenta polypeptide injection in the treatment of locally advanced oral cancer

Objective To explore the effect and safety of the combination of placenta polypeptide injection and chemotherapeutics in the treatment of locally advanced oral cancer. Methods From October 2010 to August 2012, 128 patient with locally advanced oral cancer were enrolled into this study, and ran- domly divided into the treatment group treated with placenta polypeptide injection and chemotherapeutics（65 patients） and the control group treated with chemotherapeutics （63 patients）o Patients in the treatment group received placenta polypeptide injection in the day before chemotherapy, the doses was 8ml, combined with 5% 500 ml glucose injection static drops for seven days,28 days as one cycle, a total of 4 cycleso The effect, state of systemic and drug toxicity were observed. Results The short-term effect of treatment and control group was 55.4% and 53.9% , respectively, the different had no significant （ P 〉 O. 05 ） o After chemotherapy, QOL and KPS scores in the treatment group were higher than that in the control group, the difference were significant（P 〈0. 05 ）. WBC decline in the treatment group was less than that in the control group. The incidence of nausea/vomiting and oral mucositis were lower than that in the control group, the difference were significant（P 〈0. 05）. The side effects in the two groups, such as other peripheral blood indi- cators, diarrhea, hair loss and abnormal liver function, had no significant difference （ P 〉 0. 05 ）. Conclu- sion During the chemotherapy treatment of locally advanced oral cancer, combined of placenta polypeptide injection could help to anti cancer and had good safety, it was worth to be applied in the clinical practice.