胎盘多肽注射液治疗晚期骨肿瘤的疗效观察

目的探讨胎盘多肽注射液治疗晚期骨肿瘤的临床疗效。方法选取2007年1月至2013年11月间我院收治的80例骨肿瘤患者,随机分为对照组(单纯化疗组)和观察组(化疗联合胎盘多肽注射液组),每组各40例,观察比较两组患者治疗后生活质量评分(QOL)、免疫功能、体力状况评分(KPS)及不良反应。结果与对照组比较,观察组患者治疗后QOL评分明显升高,CD+3、CD+4、CD+4/CD+8、NK细胞活性明显升高,体力较前明显改善,不良反应程度明显减轻,差异有统计学意义(P<0.05)。结论对于晚期骨肿瘤患者,胎盘多肽注射液能够改善患者生活质量,提高机体免疫力,降低不良反应及程度,值得临床推广。

Efficacy of placenta polypeptide injection in the treatment of advanced malignant bone tumor

Objective To study the clinical efficacy of placenta polypeptide injection in the treat- ment of advanced malignant bone tumor. Methods The 80 patients with advanced malignant bone tumor in our hospital during the period from Jan 2012 to Nov 2013 were randomized into the control group （ chemotherapy alone） and the observation group （chemotherapy combined with palcenta polypeptide injection）, 40 patients per group. The life quality scores （QOL）, immune function, body force scores （KPS）, and the toxicity effects in the two groups were observed and compared. Results Compared with the control group, the QOL scores was significantly increased after treatment in the observation group with statistical difference （P 〈 0. 05） ; compared with the control group, the activity of CD3＋ , CD4＋ , CD4＋/CDs and NK were obviously increased after treatment in the observation group with statistical difference （P 〈 0. 05 ） ; compared with the control group, the body force was significantly strengthened after treatment in the observation group with statistical difference （ P 〈 0. 05 ） ; compared with the control group, the degree of toxicity was obviously decreased after treatment in the observation group with statistical difference （ P 〈 0. 05）. Conclusion For the patients with advanced malignant bone tumor, placenta polypeptide injection can improve the life quality and increase the immunity, reduce the toxicity and toxic degree, and is worthy of clinical promotion.