| 大鼠主动脉球囊拉伤后一氧化氮合酶表达的变化 |
| |
| 引用本文： | 彭旭,汪丽蕙,尹航,夏春芳,田洪森,唐朝枢. 大鼠主动脉球囊拉伤后一氧化氮合酶表达的变化[J]. 中国介入心脏病学杂志, 2000, 8(2): 101-103 |
| |
| 作者姓名： | 彭旭 汪丽蕙 尹航 夏春芳 田洪森 唐朝枢 |
| |
| 作者单位： | 100034,北京医科大学第一医院心内科 |
| |
| 基金项目： | “八五”国家医学科技攻关项目!( 85 915 0 2 0 2 )，高等学校博士学科点专项科研基金资助课题!( 960 2 40 14 ) |
| |
| 摘 要： | 】
|
| 关 键 词： | 】 |
| 修稿时间： | : |
Changes of nitric oxide synthase in itimal hyperplasia following rat aortic balloon injury |
| |
| Peng Xu,Wang Lihui,Yin Hang,et al. Changes of nitric oxide synthase in itimal hyperplasia following rat aortic balloon injury[J]. Chinese Journal of Interventional Cardiology, 2000, 8(2): 101-103 |
| |
| Authors: | Peng Xu Wang Lihui Yin Hang et al |
| |
| Affiliation: | Peng Xu,Wang Lihui,Yin Hang,et al Department of Cardiology,the First Hospital of Beijing Medical University,Beijing 100034 |
| |
| Abstract: | Objective To investigate the expression of three isoforms of Nitric oxide synthase (nNOS, eNOS and iNOS) in rats following aorta balloon injury Methods Endothelial denudation of aorta in Wistar rats was performed with Forgarty 2F balloon catheter At the 1st, 3rd, 7th, 14th day following balloon injury, the rats were killed and aortas were taken out The expression of NOS was assayed by Western blot Results In normal conditions, vasa express the nNOS and eNOS Expression of iNOS was detected at the 1st day following balloon injury, peak at the 3rd, and lasted till the 14th day eNOS expression was increased by 50%, 105%, 86% and 49% at 1st, 3rd, 7th and 14th respectively, compared with the control group No changes were detected about the expression of nNOS following vascular injury Conclusion The increased expression of eNOS and iNOS may play a role in the inhibition of neointimal hyperplasia following vascular injury There is no relationship between nNOS and neointimal hyperplasia |
| |
| Keywords: | Nitric oxide synthase Intimal hyperplasia Signal transduction |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
