血管内皮细胞生长因子在肥胖乳腺癌患者乳腺癌组织中的表达及临床意义

 摘要：　目的 探讨肥胖乳腺癌患者乳腺癌组织中血管内皮细胞生长因子（vascular endothelial growth factor，VEGF）的表达及临床意义。方法 采集45例肥胖乳腺癌患者，37例正常体重乳腺癌患者，用RT-PCR和免疫组织化学检测肥胖组和正常体重组乳腺癌组织VEGF的mRNA和蛋白表达。结果 肥胖组乳腺癌组织VEGF的mRNA和蛋白表达均高于正常体重组 (P<0.05)，并且VEGF mRNA和蛋白表达之间呈正相关(r=0.785，P<0.05)；VEGF在肥胖乳腺癌组织中的表达与组织学分级、5年复发转移有关，与患者年龄无关。结论 VEGF在肥胖乳腺癌患者中具有高表达趋势，提示VEGF可能在肥胖相关性乳腺癌的发生、演变及预后中起重要作用。

Expression and significance of vascular endothelial growth factor in breast tissue in patients with breast cancer

Objective To explore the expression and clinical significance of vascular endothelial growth factor in breast tissue in obese breast cancer.Methods Breast tissue samples were collected from 45 overweighted cases with breast cancer,37 cases of normal weight with breast cancer,the expression of VEGF mRNA and protein of breast tissue were detected by RT-PCR and immunohistochemistry in obese breast cancer group and normal weight breast cancer group,and correlation was analyzed between VEGF mRNA and protein.Results Compared with normal weight breast cancer group,the expression of VEGF mRNA and protein of breast tissue in overweighted breast cancer group increased obviously(P<0.05),while the expression of VEGF mRNA and protein were positively correlated(r=0.785,P<0.05);the expression of VEGFR mRNA and protein of breast tissue in obese breast cancer group increased obviously(P<0.05),while the expression of VEGFR mRNA and protein were positively correlated(r=0.763,P<0.05);the expression of VEGF in breast tissue in obese breast cancer was relevant with 5 years′relcurrence and metastasis,regardless of age.Conclusions VEGF maybe plays an important role in occurrence,evolvement and prognosis of obesity-related breast cancer.