| 单倍型相合骨髓移植治疗难治复发恶性淋巴瘤初步观察 |
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| 引用本文： | 薛梅,王恒湘,闫洪敏,朱玲,刘静,丁丽,王志东,段连宁. 单倍型相合骨髓移植治疗难治复发恶性淋巴瘤初步观察[J]. 临床血液学杂志, 2010, 0(1) |
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| 作者姓名： | 薛梅 王恒湘 闫洪敏 朱玲 刘静 丁丽 王志东 段连宁 |
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| 作者单位： | 空军总医院血液科; |
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| 摘 要： | 目的:探讨应用单倍型未去T细胞的异基因骨髓移植(allo-BMT)治疗难治复发恶性淋巴瘤的疗效、造血重建、并发症及生存情况。方法:采用清髓性未去T细胞亲缘单倍型相合allo-BMT治疗11例难治性晚期淋巴瘤患者。供者用粒细胞刺激集落因子(G-CSF)皮下注射,连续7d后采髓,预处理方案采用环磷酰胺、全身照射及阿糖胞苷(CyTBI加Ara-C)。移植物抗宿主病(GVHD)预防采用联合免疫抑制剂包括环孢素A、短程氨甲碟呤、抗胸腺细胞球蛋白、CD25单克隆抗体及霉酚酸酯。结果:患者移植后均获造血重建,中性粒细胞>0.5×109/L及PLT>20×109/L的平均时间分别为17.2及21.3d,植入证据检测证实为完全供者造血。4例发生急性GVHD(aGVHD),3例发生慢性GVHD(cGVHD),中位随访1136(31～2521)d,2例死于感染,1例死于aGVHD,1例死于复发,无病生存7例。结论:清髓性未去T细胞亲缘单倍型相合allo-HSCT是治疗伴骨髓侵犯以及自体造血干细胞移植后复发难治性晚期恶性淋巴瘤有效方法,如有合适供者,可考虑作为年轻晚期患者的挽救治疗。
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| 关 键 词： | 淋巴瘤 异基因造血干细胞移植 难治复发 |
Prediminary study of haploidentical bone marrow transplantation for treatment in patients with aggressive or refractory lymphoma |
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| XUE Mei WANG Hengxiang YAN Hongmin ZHU LingLIU Jing DING Li WANG Zhidong DUAN Lianning. Prediminary study of haploidentical bone marrow transplantation for treatment in patients with aggressive or refractory lymphoma[J]. Journal of Clinical Hematology, 2010, 0(1) |
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| Authors: | XUE Mei WANG Hengxiang YAN Hongmin ZHU LingLIU Jing DING Li WANG Zhidong DUAN Lianning |
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| Affiliation: | Department of Hematology/a>;General Hospital of Air Force/a>;PLA/a>;Beijing/a>;100036/a>;China |
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| Abstract: | Objective:To explore the effect and hematopoietic reconstitution of haploidentical allogeneic bone marrow transplantation (allo-BMT) without T lymphocyte depletion in the patients with intractable lymphoma.Method:The 11 patients was aggressive,refractory lymphoma,or relapse after autologous HSCT (auto-HSCT) in our hospital. All patents were treated with standardized conditioning regimen consisting of high dose cytosine arabinoside (Ara-C),cyclophosphamide (CTX) and total body irradiation (TBI). The donors w... |
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| Keywords: | lymphoma Haploidentical bone marrow transplantation |
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