藏边大黄复合剂对糖尿病小鼠血糖的影响

目的：了解藏边大黄复合剂对糖尿病小鼠血糖的影响。方法：将糖尿病模型动物依据血糖水平随机分为4组，每组15只，剂量分别为0、125mg／kg、250mg／kg、750mg／kg组，即1个模型对照组（蒸馏水）和低、中、高3个实验组。经口连续给予受试物30d后取尾血测定空腹血糖值和给葡萄糖后0、0．5、2h的血糖值，观察给葡萄糖后各时间点血糖曲线下面积的变化。结果：750mg／kg剂量组能降低高血糖模型小鼠空腹血糖，与模型对照组比较差异有显著性（P〈0．05），250mg／kg、750mg／kg剂量组能减少高血糖模型小鼠血糖曲线下面积，与模型对照组比较差异有显著性（P〈0．05）。结论：藏边大黄复合剂对高血糖模型小鼠空腹血糖有明显降低血糖的效果，并能提高高血糖模型小鼠对葡萄糖的糖耐量。

THE EFFECTS OF TIBET''''S RHUBARB COMPOUND ON HYPERGLYCEMIA MICE INDUCED BY ALLOXAN

Objective:To observe the therapeutic effect of Tibet's rhubarb compound(TRC)on diabetic mice induced by injecting alloxan.Methods:Diabetic model of mice were divided into 4 groups according to their blood glucose.Four groups were orally administrated with TRC 0,125,250,750 mg/kg for 30 days,respectively.At the end of trial,blood-glucoses were measured at 0 h,0.5 h,2 h after glucose administrated with the dosage of 2 g/kg BW(blood glucose value at 0 h was equal to empty stomach).Glucose tolerance(GT)was indicated by area under the curve of blood glucose(ACBG).Results:Blood glucoses in 750 mg/kg group were significantly decreased compare to control group at 0 h(P<0.05).The ACBGs in the 250 mg/kg and the 750 mg/kg groups were significantly lower than control group(P<0.05).Conclusion:TRC had effects of decredsing blood glucose and improving GT in diabetic model of mice induced by alloxan.