骨骼肌组织工程种子细胞来源的研究进展

构建组织工程骨骼肌的种子细胞有肌卫星细胞、成肌细胞、胚胎干细胞、间充质来源的干细胞(包括骨髓来源干细胞、羊水来源干细胞、脂肪来源干细胞等).不同来源的种子细胞在体内、外均能向肌细胞系分化,或与肌源系细胞融合,表达肌源系细胞表面抗原,参与肌纤维的修复.这些种子细胞均有望构建组织工程化骨骼肌.对目前骨骼肌组织工程种子细胞来源进行综述. Abstract： Different cells could be utilized as seed cells in the construction of tissue-engineered skelet al muscle, which include satellite stem cells, myohlasts, embryonic stem cells and mesenchymal stem cells includ-ing bone marrow-derived stem cells, amniotic fluid-derived stem cells, and adipose tissue-derived stem cells. Seed cells from different origins are capable of trans-differentiating into myogenic cells or fusing with myogenic cells, expressing the surface antigen of sarcogenic cells, and participating in the regeneration of muscle fiber, both in vivo and ex vivo. This review gives a summarization of the recent progress in the research on seed cell source in skelet al muscle tissue engineering.

Progress in the reseach on seed cell source in skeletal muscle tissue engineering

Different cells could be utilized as seed cells in the construction of tissue-engineered skelet al muscle, which include satellite stem cells, myohlasts, embryonic stem cells and mesenchymal stem cells includ-ing bone marrow-derived stem cells, amniotic fluid-derived stem cells, and adipose tissue-derived stem cells. Seed cells from different origins are capable of trans-differentiating into myogenic cells or fusing with myogenic cells, expressing the surface antigen of sarcogenic cells, and participating in the regeneration of muscle fiber, both in vivo and ex vivo. This review gives a summarization of the recent progress in the research on seed cell source in skelet al muscle tissue engineering.