Abstracts of Articles on Vitamins |
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Authors: | Bernard Herbeth Sonia Gueguen Pierre Leroy Gérard Siest Sophie Visvikis-Siest |
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Institution: | 1. INSERM (B.H., S.G., G.S., S.V.S.);2. Université Henri Poincaré, Faculté de Pharmacie (B.H., G.S., S.V.S., P.L.), Nancy, FRANCEBernard.Herbeth@nancy.inserm.fr;4. Université Henri Poincaré, Faculté de Pharmacie (B.H., G.S., S.V.S., P.L.), Nancy, FRANCE;5. Université Henri Poincaré, Faculté de Pharmacie (B.H., G.S., S.V.S., P.L.), Nancy, FRANCE |
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Abstract: | Background: Carotenoids are mainly carried by lipoproteins in blood, however little is known about the influence of polymorphisms of apolipoproteins (apo), cholesterol ester transfer protein (CETP) and lipoprotein lipase (LPL) involved in serum lipid metabolism.Objective: We aimed to analyze whether serum concentrations of 5 carotenoids (lutein-zeaxanthin, β-cryptoxanthin, lycopene, α-carotene, β-carotene) are associated with common polymorphisms of Apo E, Apo B, Apo CIII, CETP, and LPL.Methods: Serum concentrations of lutein-zeaxanthin, β-cryptoxanthin, lycopene, α-carotene, and β-carotene were measured and polymorphisms of Apo E (cys112arg and arg158cys), Apo B (thr71ile), Apo CIII C(?482)T, Apo CIII T(?455)C, Apo CIII C1100T, Apo CIII C3175G, Apo CIII T3206G], CETP (ile405val), and LPL (S447X) were determined in a sample of 447 children and adults drawn from the Stanislas Study.Results: After adjustment for age, sex, smoking, physical activity, oral contraceptive use, BMI, serum cholesterol and triglyceride concentrations, and fruit and vegetable intakes, carriers vs. non carriers of the lipoprotein lipase X447 allele had significant lower concentrations of lutein-zeaxanthin, β-cryptoxanthin, α-carotene and β-carotene; differences vs. S447S genotype being the largest for X447X: ?18.8%, ?50.5%, ?54.8% and ?47.1%, for the four carotenoid fractions, respectively. No significant association was noticed for lycopene concentration. None of the other tested polymorphisms was significantly related to the serum carotenoid concentrations.Conclusions: Our investigation for the first time demonstrates that LPL S447X polymorphism could alter serum concentrations of carotenoids in healthy individuals, independently of serum cholesterol and triglyceride concentration. These data indicate that genetic factors could be involved in the variability of carotenoid bioavailability and bioconversion. |
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Keywords: | lutein-zeaxanthin β-cryptoxanthin lycopene carotene lipoprotein lipase S447X polymorphism |
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