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Synthesis and biodistribution of [18F]-5-fluorocytosine |
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| Authors: | G W Visser S Boele G H Knops J D Herscheid A Hoekstra |
| Abstract: | [18F]-5-fluorocytosine was prepared by reaction of [18F]-acetylhypofluorite with cytosine in acetic acid and was isolated in an overall radiochemical yield of 20%. Tissue distribution studies in sarcoma-bearing rats indicated in vivo stability, limited tissue uptake and rapid urinary excretion. |
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