| 反相高效液相色谱法测定利巴韦林注射液的有关物质 |
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| 引用本文： | 吴宏富,刘放. 反相高效液相色谱法测定利巴韦林注射液的有关物质[J]. 中国药业, 2009, 18(7): 17-18 |
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| 作者姓名： | 吴宏富 刘放 |
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| 作者单位： | 1. 浙江省庆元县中医院,浙江,庆元,323800
2. 浙江省医学科学院药物研究所,浙江,杭州,310013 |
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| 摘 要： | 目的建立测定利巴韦林注射液有关物质的反相高效液相色谱（RP-HPLC）法。方法采用Hypersil C18色谱柱（250mm×4．6mm，10μm），以水为流动相，检测波长为207nm。结果利巴韦林及其有关物质达到基线分离，方法的最低检测量为2．5ng。结论方法简便、快速、准确，适用于利巴韦林及其制剂的质量控制。
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| 关 键 词： | 利巴韦林 利巴韦林注射液 有关物质 反相高效液相色谱法 |
Determination of Related Substances in Ribavirin Injection by RP-HPLC |
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| Wu Hongfu,Liu Fang. Determination of Related Substances in Ribavirin Injection by RP-HPLC[J]. China Pharmaceuticals, 2009, 18(7): 17-18 |
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| Authors: | Wu Hongfu Liu Fang |
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| Affiliation: | 1. Qingyuan Hospital of Traditional Chinese Medicine, Qingynan, Zhejiang, China 323800; 2. Institute of Matera Medica, Zhejiang Academy of Medical Sciences, Hangzhou, Zhefiang, China 310013) |
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| Abstract: | Objective To establish a RP- HPLC method for the determination of relevant substances in Ribavirin Injection. Methods The RP- HPLC method was used. Chromatographic condition included the Hypersil C18 column with the mobile phase of water. The UV detection wavelength was set at 207 nm. Results The peak of ribavirin and its related substances were separated completely. LOD was 2.5 ng. Conclusion The method is simple, rapid and accurate, which can be used to control the quality of ribavirin and its preparations. |
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| Keywords: | ribavirin Ribavirin Injection related substances RP - HPLC |
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