原发孤立性肝癌经导管化疗栓塞后血清VEGF表达与碘油沉积的相关性

目的：探讨原发孤立性肝细胞肝癌（HCC）经导管化疗栓塞（TACE）治疗前后血清血管内皮细胞生长因子（VEGF）表达与碘油沉积的相关性。方法：采用酶联免疫夹心法（ELISA）对38例HCC患者分别于第一次TACE术前1天、术后1周、术后2周、术后1月及术后2月测量其血清VEGF表达水平,同期测量瘤体内碘油沉积的体积百分比,然后进行两者的相关性分析。结果：术后1天血清VEGF呈一过性增高,术后1周VEGF的表达降至低谷,于术后2周开始缓慢上升,术后2月血清VEGF值较术后1月明显升高。血清VEGF的高表达与TACE后局部复发密切相关,血清VEGF值越高,其TACE疗效越差。血清VEGF值与碘油沉积率在术后1天、术后1月和术后2月有显著相关性。结论：血清VEGF与碘油沉积率在评价TACE疗效中有较好的相关性,联合测量血清VEGF表达与碘油沉积率可较好地评价TACE的疗效。

The relationship between the serum VEGF and lipiodol retention after transcatheter arterial embolization of the solitary type hepatocellnlar carcinoma

Objective：To study the relationship between the serum vascular endothelial growth factor （VEGF） and lipiodol retention after transcatheter arterial embolization（TACE） of the solitary type hepatocellular carcinoma（HCC）. Methods：Serum VEGF expression level, was measured by quatitative sandwich enzyme -linked immunosorbentassay （ELISA,R＆D system） , before TACE 1 day and 1 day,1 week, 2 weeks, 1 month, 2 months after TACE in 36 patients with HCC,and the percentage of lipiodol retention to the total tumor volume were measured at the same time. Results： The serum VEGF level reached a peak at 1 day after TACE, then decreased after 1 week, increased again after 2 weeks, then gradually rised to 2 months after TACE. Serum VEGF expression increase was associated with the development of recurrence in hepatocellular carcinoma after TACE. The prognosis of the patients with rising VEGF concetrations was dismal. A significant correlation existed between the serum VEGF level and the percentage of lipiodol retention of 1 day, 1 month and 2 months after TACE. Conclusion： It is useful to test the serum VEGF level and the percentage of lipiodol retention, and may be as a novel prognostic predictor of the HCC treated by TACE treatment.