慢加急性乙型肝炎肝功能衰竭患者血浆降钙素原测定的临床意义

目的探讨慢加急性乙型肝炎肝功能衰竭患者血浆降钙素原(PCT)水平的变化及其临床意义。方法 59例慢加急性乙型肝炎肝功能衰竭患者计算MELD评分,根据预后分为存活组26例及死亡组33例,测定血浆降钙素原水平。结果死亡组患者血浆PCT阳性率、血浆PCT水平均高于存活组(P<0.05);MELD评分>30组患者血浆PCT水平高于MELD评分≤30组(P<0.05);患者血浆PCT与MELD评分呈正相关(rp=0.318,P<0.05)。结论慢加急性乙型肝炎肝功能衰竭患者血浆降钙素原水平在评价疾病严重程度及预后判断有一定价值。

The Clinical Significance of Measurement of Serum Procalcitonin in Patients with Acute-on-chronic Hepatitis B Liver Failure

Objective To investigate the changes and the clinical significance of serum procalcitonin （PCT） in patients with acute-on-chronic hepatitis B liver failure. Methods According to the clinical outcome, 59 patients with acute-on-chronic hepatitis B liver failure were divided into survival group （n=26） and death group （n=33）. Register the MELD score and measure the levels of serum procalcitonin of the patients. Results Patients in death group had a higher positive rate and a higher value of serum procalcitouin than those in survival group（P〈0.05）. Patients in MELD score 〉30 group had a higher value of serum procalcitonin than those in MELD score ≤ 30 group （P 〈0.05）. There was a positive correlation between the value of serum procalcitonin and MELD score （rp =0.318, P〈0.05）. Conclusions The value of serum procalcitonin may be helpful in predicting the severity of the illness and prognosis in patients with acute- on-chronic heoatitis B liver failure.