5例B型流感嗜血杆菌脑膜炎病例流行病学特征分析

目的 分析Hib(b型流感嗜血杆菌)脑膜炎病例的特征.方法 采用前瞻性观察研究的方法,2007年5月至2009年12月期间,在随机抽取的4个县(市)、区的6所各级各类医院中主动开展脑炎、脑膜炎症状监测,对收集到的血、脑脊液标本进行Hib细菌培养和RT-PCR检测.结果 首次在河北省检出5例Hib脑膜炎病例,均为6-12...

Epidemiological characteristics of haemophilus influenzae type b meningitis cases in Hebei province

Objective To analyze the epidemiological characteristics,clinical features and laboratory detection results of haemophilus influenzae type b（Hib）.meningitis cases.Methods The active surveillance of encephalitis and meningitis was conducted in 6 hospitals in 4 randomly selected counties（district） in Hebei from May 2007 to December 2009.The blood and cerebrospinal fluid（CSF） samples were collected to conduct Hib culture and RT-PCR detection.Results Five cases of Hib meningitis were detected for the first time in Hebei,the incidence was about 0.36/lakh.The cases mainly occurred in Autumn and Winter and all were infants age 6-12 months in rural area,who were without Hib vaccination history and had taken antibiotics 1 week before sample collecting.The interval between initial medical seeking and final medical seeking was long.Their clinical symptoms and laboratory detection results were atypical.The cases were all had good prognosis and without sequela.Conclusion It is suggested to take samples from the children diagnosed as bacterial meningitis to conduct bacterial culture and conduct RT-PCR when it is possible,and it is suggested to conduct intensive surveillance of acute encephalitis and meningitis symptoms in China,and on the basis of the surveillance,nested case-control study should be conducted to evaluate the Hib infection status,risk factors and diseases burden accurately and feasibility of inclusion of Hib vaccine into EPI program.