| 芒果苷对垂体后叶素诱发小鼠心肌缺血的保护作用 |
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| 引用本文： | 韦健全,郑子敏,潘勇,罗莹,黄健,赖术,许小林. 芒果苷对垂体后叶素诱发小鼠心肌缺血的保护作用[J]. 右江民族医学院学报, 2008, 30(4): 534-535 |
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| 作者姓名： | 韦健全 郑子敏 潘勇 罗莹 黄健 赖术 许小林 |
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| 作者单位： | 右江民族医学院药理学教研室,广西,百色,533000 |
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| 摘 要： | 目的观察芒果苷(mangiferin)对垂体后叶素(pituitrin,PIT)诱发小鼠心肌缺血的影响。方法采用腹腔注射PIT 30u/kg建立小鼠急性心肌缺血模型,观察芒果苷对小鼠Ⅱ导联心电图(ECG),心肌超氧化物岐化酶(SOD),丙二醛(MDA)及血清磷酸肌酸激酶(CK)和乳酸脱氢酶(LDH)的影响。结果芒果苷对PIT诱发小鼠Ⅱ导联ECG异常有改善(P<0.05)。芒果苷使心肌SOD活性明显升高,使心肌MDA含量、血清CK及LDH水平降低(P<0.05或0.01)。结论芒果苷对垂体后叶素诱发小鼠心肌缺血的损伤有保护作用。
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| 关 键 词： | 芒果苷 垂体激素类,后叶 心肌缺血 小鼠 动物实验 |
Effects of Mangiferin on myocardial ischemia induced by pituitrin in mice |
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| WEI Jian-quan,ZHENG Zi-min,PAN Yong,LUO Ying,HUANG Jian,LAI Shu,XU Xiao-lin. Effects of Mangiferin on myocardial ischemia induced by pituitrin in mice[J]. Journal of Youjiang Medical College For Nationalities, 2008, 30(4): 534-535 |
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| Authors: | WEI Jian-quan ZHENG Zi-min PAN Yong LUO Ying HUANG Jian LAI Shu XU Xiao-lin |
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| Affiliation: | WEI Jian-quan,ZHENG Zi-min,PAN Yong,LUO Ying,HUANG Jian,LAI Shu,XU Xiao-lin (Department of Pharmacology,Youjiang Medical College for Nationalities,Baise,Guangxi 533000,China) |
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| Abstract: | Objective To evaluate the protection of mangiferin(MAN) against mice myocardial ischemia induced by pituitrin(PIT).Methods Acute myocardial ischemic models were obtained by intra-peritoneal administration of PIT 30u/kg in mice.Meanwhile,the mice were also intraperitoneal admnistration with different concentrations of MAN once daily for 7 days.The fluctuations of lead II on ECG,the myocardial SOD and MDA,the serum levels of LDH and CK were measured.Results MAN could ameliorate the abnormal changes of ECG(P<0... |
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| Keywords: | mangiferin pituitrin myocardial ischemia mice animal experiments |
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