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Modulation of azoxymethane-induced mutational activation of ras protooncogenese by chemopreventive agents in colon carcinogenesis
Authors:Singh, Jagveer   Kulkarni, Nalini   Kelloff, Gary   Reddy, Bandaru S.
Affiliation:American Health Foundation, Division of Nutritional Carcinogenesis One Dana Road Valhalla, NY 10595
1National Cancer Institute, Chemoprevention Branch, Division of Cancer Control and Prevention Bethesda, MD 20892, USA
Abstract:In our previous study, we demonstrated that azoxymethane (AOM)treatment significantly enhanced the expression of ras p21,the protein product of ras genes, and that the dietary administrationof chemopreventive agents such as D, L,
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