羟基喜树碱联合化疗治疗晚期大肠癌近期疗效分析

目的观察以羟基喜树碱为主的联合化疗方案治疗晚期大肠癌的近期疗效及毒副反应.方法 HCPT 8～10 mg/m2,静脉滴注,第1～5天;DDP 20 mg/m2,静脉滴注,第1～3天;CF 100 mg/d,静脉滴注,第1～5天;5-Fu 300 mg/m2,静脉滴注,第1～5天,每21～28 d为一周期,2周期为一疗程.结果 39例均可评价疗效,CR 0例,PR 17例,SD 16例,PD 6例.有效率(CR PR)43.6%,化疗受益率(CR PR SD)84.6%.初治有效率为50.0%,化疗受益率90.6%.毒副反应主要为骨髓抑制和消化道反应.结论羟基喜树碱为主的联合化疗疗效高,毒副反应可耐受.

Efficacy of combined chemotherapy containing hydroxycamptothecine in the treatment of advanced colorectal cancer

Objective To evaluate the efficacy and toxicity of combined chemotherapy containing hydroxycamptothecine(HCPT) in the treatment of advanced colorectal cancer.Methods HCPT 8-10 mg/m~2,CF 100 mg/d,5-Fu 300 mg/m~2,iv infusion d1-5,DDP 20 mg/m~2 iv infusion d1-3.The regimen was repeated every 3 or 4 weeks as 1 cycle.One course consisted of two cycles.Results Thirty-nine cases of advanced colorectal carcinoma were evaluated for efficacy.No one achieved CR,17 PR,16 SD,and 6 PD.Overall response rate was 43.6%,benefit rate was 84.6%.In the primary treatment,the RR was 50.0%,the benefit rate was 90.6%.The main side effects were myelosuppression,nausea,vomiting and diarrhea.Conclusion Combined chemotherapy with HCPT-containing regimen showed higher efficacy and low toxicity.