Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis |
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| Authors: | Hiroki Tojima Satoru Kakizaki Takashi Kosone Norio Horiguchi Yuichi Yamazaki Ken Sato Hitoshi Takagi Masatomo Mori |
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| Affiliation: | (1) Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi Gunma, 371-8511, Japan; |
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| Abstract: | Background Hepatocyte growth factor (HGF) is a potent growth factor involved in liver regeneration that has various effects on epithelial and nonepithelial cells. Although it has been demonstrated that HGF can reduce liver inflammation or fibrosis caused by pharmaceutical or chemical insult, no examination of its effect on liver injury in nonalcoholic steatohepatitis (NASH) has been reported. |
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