| 血液灌流对维持性血液透析患者成纤维细胞生长因子23的影响 |
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| 引用本文： | 张军力,宦红娣,张景红,李萍,陆蓓莉,杨黄,杨峻.血液灌流对维持性血液透析患者成纤维细胞生长因子23的影响[J].中国临床医学,2009,16(4):594-596. |
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| 作者姓名： | 张军力 宦红娣 张景红 李萍 陆蓓莉 杨黄 杨峻 |
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| 作者单位： | 中国人民解放军85医院肾内科,上海,200052 |
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| 摘 要： | 目的：观察血液灌流（HP）对维持性血液透析（HD）患者血清成纤维细胞生长因子23（FGF-23）的影响及其可能的作用机制。方法：测定15例HD患者血液灌流前、后血清FGF-23、全段PTH（iPTH）及血清肌酐、钙、磷等指标。透析方案：血液灌流联合血液透析1次／2周，HD5次／2周，总共12次为1个疗程。结果：单次HP患者的血清肌酐水平均明显下降（P〈0．05）。HP治疗12次后患者FGF-23（88．51±35．0ng·L^-1）、血磷（87．85±33．65ng·L^-1）均明显下降。结论：血液灌流可降低HD患者FGF-23水平，改善血磷代谢。
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| 关 键 词： | 成纤维细胞生长因子23 血液灌流 磷 维持性血透 |
Effect of Hemoperfusion on the Level of Serum Fibroblast Growth Factor 23 in Hemodialysis Patients |
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| ZHANG Junli,HUAN Hongdi,ZHANG Jinghong,LI Ping,LU Beili,YANG Huang,YANG Jun.Effect of Hemoperfusion on the Level of Serum Fibroblast Growth Factor 23 in Hemodialysis Patients[J].Chinese Journal Of Clinical Medicine,2009,16(4):594-596. |
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| Authors: | ZHANG Junli HUAN Hongdi ZHANG Jinghong LI Ping LU Beili YANG Huang YANG Jun |
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| Institution: | ZHANG Junli HUAN Hongdi ZHANG Jinghong LI Ping LU Beili YANG Huang YANG Jun Department of Nephorology,the 85th Hospital of PLA of China,Shanghai 200052,China |
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| Abstract: | Objective： To explore the effect of hemoperfusion on the level of werum fibroblast growth factor-23 in hemodialysis patients. Methods：Serum FGF23 was detected by enzyme-linked immunosorbent assy（ELISA） before and after hemoperfusion in a cohort of 15 HD patients. Serum intact PTH ,creatinine,calcium and phosphorus were also measured at the same time. Results： Serum FGF-23 was significantly higher in HD patients（534.50 ± 106.38pg/ml vs 11.76 ± 3.63 pg/ml）. After a period of hemoperfusion, serum FGF-23 and phosphorus was much downregulated,as well as iPTH and TG. Conclusion： Serum FGF-23 is significantly downregulated after a long term of hemoperfusion. Maybe it can regulate the metabolism of phosphorus. |
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| Keywords: | Fibroblast growth factor-23 Hemoperfusion Hemodialysis Phosphorus |
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