N,N'-〔2,2'-二硫双(苯甲酰)〕-双 N-环己烷甘氨酸的降压作用

用麻醉大鼠观察了Ｎ，Ｎ′－〔２，２′－二硫双（苯甲酰）〕－双Ｎ－环己烷甘氨酸（ＤＧ－Ｉ）对血流动力学的影响、对肾血管性高血压的抗高血压作用及对ＡＩ、ＢＫ血压反应影响。ＤＧ－Ｉ２ｍｇ·ｋｇ－１ｉｖ可降低正常麻醉大鼠之ＳＡＰ、ＤＡＰ，不伴有ＬＶＰ、±ｄＰ／ｄｔｍａｘ下降，亦无反射性ＨＲ增快。ＤＧ－Ｉ２，４ｍｇ·ｋｇ－１ｉｖ可使肾血管性高血压大鼠血压下降，４ｍｇ·ｋｇ－１组伴有ＨＲ减慢。ＤＧ－Ｉ依剂量抑制ＡＩ之升压效应并增强ＢＫ之降压反应。结果表明ＤＧ－Ｉ具有血管紧张素转化酶抑制剂之特点，其降压作用与此有关。

Hypotensive effects of N,N′ (2,2′ Disulf Di benzoyl) Di N cyclohexane glycine

N, N′ (2,2′ Disulf Di benzoyl) Di N cyclohexane glycine (DG I) is a novel nonsulfhydryl angiotensin converting enzyme inhibitor. The hemodynamic effects of DG I and captopril by iv 2 mg·kg -1 on pentobarbital anesthetized normorensive rats and antihypertensive effects of DG I by iv 2, 4 mg·kg -1 on pentobarbital anesthetized renal hypertensive rats were studied respectively. DG I 2 mg·kg -1 iv lowered only SAP, DAP from 15 7±2 3, 11 8±2 3 kPa to 13 8±2 9, 9 5±3 6 kPa( P <0 05) respectively, but LVP, ±d P /dt max did not show significant influence and did not produce a reflex tachycardia. Both DE I and captopril 2 mg·kg -1 iv showed the same hypotensive potency( P>0 05 ). DG I 2 or 4 mg·kg -1 iv depressed blood pressure in renal hypertensive rats. DG I 4 mg·kg -1 diminished heart rate. Pretreament with DG I iv could significantly reduce the pressor and bradycardic effects to AI, increase the hypotensive response to BK, but the tachycardia was unchanged significantly. The results suggest that DG I evoked fall in blood pressure is related to the inhibition of ACE.