Use of a single [123I]-FP-CIT SPECT to predict the severity of clinical symptoms of Parkinson disease |
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Authors: | Ruth Djaldetti Therese A. Treves Ilan Ziv Eldad Melamed Yair Lampl Mordechai Lorberboym |
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Affiliation: | (1) Department of Neurology, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqwa, Israel;(2) Departments of Neurology, Edith Wolfson Medical Center, Holon, Israel;(3) Departments of Nuclear Medicine, Edith Wolfson Medical Center, Holon, Israel;(4) Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel |
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Abstract: | The aim of this study was to assess the ability of a single SPECT performed in the early stage of Parkinson’s disease (PD) to predict disease severity in 19 patients with early PD. [123I]-FP-CIT striatal uptake was expressed as a ratio of specific:nonspecific uptake for defined brain areas. Clinical severity was determined by the UPDRS at baseline and 12–15 months following the SPECT procedure. [123I]-FP-CIT uptake in the contralateral putamen and striatum was correlated with UPDRS score at baseline, with a more significant correlation after 1-year interval. [123I]-FP-CIT uptake in all areas was correlated with bradykinesia and rigidity subscores only at follow up visit. Significant correlations were found between [123I]-FP-CIT uptake in the contralateral striatum, putamen and caudate and the difference between motor scores of 1-year interval (ΔUPDRS). These results suggest that disease severity might be anticipated by a single SPECT at an early stage of the disease. |
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Keywords: | [123I]-FP-CIT Parkinson’ s disease Prediction Disease severity |
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