| RGD多肽对MSCs在壳聚糖/羟基磷灰石支架上黏附行为的调控 |
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| 引用本文： | 曲志伟,李保强,庄金鹏,闫曦,闫景龙.RGD多肽对MSCs在壳聚糖/羟基磷灰石支架上黏附行为的调控[J].哈尔滨医科大学学报,2011,45(3):199-202. |
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| 作者姓名： | 曲志伟 李保强 庄金鹏 闫曦 闫景龙 |
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| 作者单位： | 1. 哈尔滨医科大学附属第一医院,骨科
2. 哈尔滨工业大学,特种陶瓷研究所,黑龙江,哈尔滨,150001 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的 研究RGD多肽修饰CS/HA复合多孔支架对于MSCs在支架上黏附的数量及质量.方法 通过原位杂化法制备CS/HA多孔支架并应用物理吸附的方法将RGD多肽负载到支架表面制备出CS/HA-RGD复合支架并对其表征.分别将从Wistar大鼠提取并培养的MSCs种植到实验组CS/HA-RGD及对照组CS/HA两种支架各1...
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| 关 键 词： | 壳聚糖 羟基磷灰石 RGD多肽 多孔支架 |
Regulation of RGD peptide for adhesion behavior of MSCs on the CS/HA scaffolds |
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| QU Zhi-wei,LI Bao-qiang,ZHUANG Jin-peng,YAN Xi,YAN Jing-long.Regulation of RGD peptide for adhesion behavior of MSCs on the CS/HA scaffolds[J].Journal of Harbin Medical University,2011,45(3):199-202. |
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| Authors: | QU Zhi-wei LI Bao-qiang ZHUANG Jin-peng YAN Xi YAN Jing-long |
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| Institution: | QU Zhi-wei1,LI Bao-qiang2,ZHUANG Jin-peng1,YAN Xi1,YAN Jing-long1(1.Department of Orthopedics,The First Affiliated Hospital of Harbin Medical University,2.Institute for Advanced Ceramics,Harbin Institute of Technology,Harbin 150001,China) |
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| Abstract: | Objective To study the regulation of RGD for chitosan/hydroxyapatite(CS/HA) scaffold with channel/spherical pore in order to detect cell adhesion rate and quality on scaffold.Methods The CS/HA scaffold was prepared via in situ hybridization.Physical adsorption method was applied to load RGD peptide on the stent surface,CS/HA-RGD scaffolds was prepared and marked.MSCs extracted and cultured from Wistar rats were planted to the experimental group CS/HA-RGD(n=10) and control group CS/HA(n=10) and given combine... |
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| Keywords: | chitosan hydroxyapatite RGD peptide porosity scaffold |
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