Biological mechanisms of disease and death in Moscow: rationale and design of the survey on Stress Aging and Health in Russia (SAHR) |
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| Authors: | Maria Shkolnikova Svetlana Shalnova Vladimir M Shkolnikov Victoria Metelskaya Alexander Deev Evgueni Andreev Dmitri Jdanov James W Vaupel |
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| Affiliation: | (1) Federal Arrhythmia Centre, Moscow Institute of Pediatry and Surgery, Moscow, Russia;(2) Laboratory of Survival and Longevity, Max Planck Institute for Demographic Research, Rostock, Germany;(3) Department of Epidemiology of Non-Communicable Diseases, State Research Centre for Preventive Medicine, Moscow, Russia;(4) Laboratory of Demographic Data, Max Planck Institute for Demographic Research, Rostock, Germany;(5) Laboratory of Biochemistry, State Research Centre for Preventive Medicine, Moscow, Russia;(6) Laboratory of Biostatistics, State Research Centre for Preventive Medicine, Moscow, Russia |
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| Abstract: | Background Prior research has revealed large differences in health and mortality across countries, socioeconomic groups, and individuals. Russia experiences one of the world's highest levels of all-cause and cardiovascular mortality, great mortality differences within the population, and a heavy burden of ill health. Psychological stress has been suggested as a likely explanation of health loss and premature death in Russia and Eastern Europe. However, physiological mechanisms connecting stress with health in Russia remain unclear since existing epidemiological data are scarce and limited to conventional risk factors. |
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