| 海洛因依赖大鼠海马CA3区 PS幅值的变化 |
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| 引用本文： | 肖邦,潘贵书.海洛因依赖大鼠海马CA3区 PS幅值的变化[J].贵阳医学院学报,2011,36(2):143-146. |
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| 作者姓名： | 肖邦 潘贵书 |
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| 作者单位： | 遵义医学院生理学教研室,贵州遵义,563003 |
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| 摘 要： | 目的:应用细胞外电生理记录方法观察海洛因依赖大鼠海马CA3区的长时程增强(LTP)变化.方法:将40只SD大鼠随机分成海洛因依赖组、海洛因+MK801组、海洛因戒断组及空白对照组,在体记录由刺激海马外侧穿通纤维(1ateral perforant path,LPP)所诱发的CA3区细胞群体峰电位幅值(PS幅值).结果:...
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| 关 键 词： | 海洛因依赖 长时程增强 海马 大鼠 Sprague-Dawley |
A Study on Long-term Potentiation Changes in Hippocampus CA3 Area of Heroin Dependent Rats |
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| XIAO Bang,PAN Guishu.A Study on Long-term Potentiation Changes in Hippocampus CA3 Area of Heroin Dependent Rats[J].Journal of Guiyang Medical College,2011,36(2):143-146. |
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| Authors: | XIAO Bang PAN Guishu |
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| Institution: | (Department of Physiology,Zunyi Medical College,Zunyi 563003,Guizhou,China) |
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| Abstract: | Objective: To observe the long-term potentiation(LTP) changes in hippocampus CA3 area of heroin dependent rats with the method of extracellular electrophysiological recording.Methods: Forty SD rats were randomly divided into four groups: heroin dependent group(group HD),heroin+MK-801 group(group HM),heroin abstinence group(group HA) and control group(group C).Population spikes of cells in CA3 region of each group were recorded in vivo.LTP effect induced by high-frequency stimulations was observed.Results: After tetanic stimulation,the change rates of population spike in group HA were significantly lower than those in groups HM,HD and C at time points of 1,5,10,20,30,40,50,and 60 minutes,and no significant difference was found among the latter 3 groups.Conclusions: The LTP effect is impaired in heroin abstinence rats. |
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| Keywords: | heroin dependence long-term potentiation increase hippocampus rat Sprague-dawley |
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