联合检测氨基末端脑利钠肽和C反应蛋白在急性冠脉综合征患者中的预后价值

目的：探讨急性冠脉综合征（acute coronary syndrome,ACS）患者血浆氨基末端脑利钠肽（NT-proBNP）、C-反应蛋白（CRP）的联合检测对ACS的预后判断价值。方法：选取在本院就诊的215例ACS患者测其NT-proBNP、CRP以及心肌肌钙蛋白-I（TN-I）等水平。平均随访246 d,对NT-proBNP、CRP等生化指标与心脏不良事件（major adverse cardiac events,MACE）发生率的相关性进行统计学分析。结果：215例患者中24例发生了主要MACE,其NT-proBNP、CRP水平明显高于未发生组,COX比例风险模型分析显示：NT-proBNP、CRP是预测ACS患者是否发生终点事件的独立预测因子。ROX曲线显示当CRP〉3.5 mg/L、NT-proBNP〉500 pg/mL时,预测MACE的敏感度及特异度最强。结论：联合检测NT-proBNP、CRP对ACS患者的风险评估具有重要的临床意义。

Prognostic value of N-terminal pro-B-type natriuretic peptide and C-reactive in acute coronary syndrome

Objective: To investigate influencing factors of ACS and evaluate the prognostic ability of both NT-proBNP and CRP in patients with ACS.Methods: The baseline levels of NT-proBNP,CRP and TN-I were measured in 215 patients with ACS,all of the patients were followed up for average 246 days.All the MACE were recorded and statistically analyzed with the laboratory parameters.Results: MACEs were recorded in 24 patients and the levels of NT-proBNP,CRP were significantly higher in the patients with MACE than that i...