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Benzodiazepine Reception in C57Bl/6 and BALB/c Mice Depending on the Type of Stress Factor |
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| Authors: | K S Chekina M A Yarkova and S B Seredenin |
| Institution: | (1) Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bldg. 35, Rm. 1C912, 35 Convent Drive, Bethesda, MD, USA;(2) Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, MSC-1026, Bldg. 10, Rm. B1D43, Bethesda, MD, USA;(3) Johnson and Johnson Pharmaceutical Research and Development, 1125 Trenton-Harbourton Road, E32000 Titusville, NJ, USA |
| Abstract: | Specific binding of 3Н-fl unitrazepam with synaptosomal membranes after exposure to open field test and “contact with predator” test was measured in C57Bl/6 and BALB/c mice. Stress-induced decrease in benzodiazepine binding after open field test was observed only in BALB/c mice and after contact with predator in both animal strains. |
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