血清骨形成蛋白-7浓度与女性肥胖的相关性研究

目的检测女性血清骨形成蛋白-7浓度,探讨骨形成蛋白-7与女性肥胖的相关性。方法选取女性肥胖者65例,以体质量指数正常女性134例作为对照组。记录年龄、腰围、臀围、身高、体质量等人体学指标,计算腰臀比和体质指数。测定血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、血糖、尿酸等代谢指标,酶联免疫吸附试验(en-zyme-linked immunosorbent assay,ELISA)检测血清骨形成蛋白-7浓度,比较两组间指标的差异以及血清骨形成蛋白-7和代谢性指标的相关性。结果肥胖组血清骨形成蛋白-7浓度明显低于正常对照组(P<0.01)。女性血清骨形成蛋白-7浓度与年龄、体质指数、收缩压、腰围、总胆固醇、低密度脂蛋白胆固醇均存在负相关(r值分别为-0.181、-0.248、-0.143、-0.148、-0.169、-0.177,P<0.05),多元线性回归分析显示通过年龄、体质指数、收缩压、腰围、总胆固醇、低密度脂蛋白胆固醇、舒张压、平均动脉压、腰臀比、尿酸、甘油三酯、高密度脂蛋白胆固醇、空腹血糖校正后,血清骨形成蛋白-7仍和体质指数负相关(r=-0.248,P<0.01)。结论女性血清骨形成蛋白-7浓度与体质指数负相关,提示血清骨形成蛋白-7可能作为治疗女性肥胖的潜在靶点。

Correlation between concentration of serum bone morphogenetic protein-7 and obesity in adult women

Objective To measure serum bone morphogenetic protein-7(BMP-7) concentration in adult women and to determine correlation between BMP-7 concentration and obesity,so as to provide a new target for obesity therapy.Methods Sixty-five obese women were enrolled in an obesity group,and one hundred and thirty-four adult women having normal body mass indexes were enrolled in a control group.Clinical data including age,height,weight,systolic blood pressure,diastolic blood pressure,waist circumference,and hip circumfe...