| 铜绿假单胞菌在碳青霉烯类治疗过程中由敏感株发展为耐药株的机制研究 |
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| 引用本文： | 沈继录,方亚平,徐元宏,王中新.铜绿假单胞菌在碳青霉烯类治疗过程中由敏感株发展为耐药株的机制研究[J].安徽医学,2011,32(5):624-629. |
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| 作者姓名： | 沈继录 方亚平 徐元宏 王中新 |
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| 作者单位： | 安徽医科大学第一附属医院检验科,合肥,230022;安徽医科大学第二附属医院检验科,合肥,230601 |
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| 基金项目： | 安徽省卫生厅科研课题，安徽医科大学第一附属医院博士科研启动基金 |
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| 摘 要： | 目的 研究1例铜绿假单胞菌感染患者在接受抗菌药物治疗过程中其感染病原菌铜绿假单胞菌对碳青霉烯类抗菌药物由敏感株发展为耐药株的耐药机制.方法 收集感染患者治疗过程中分离的铜绿假单胞菌敏感株和耐药株共2株,查阅病史并对该2株菌进行:①PFGE分析其同源性,②SDS-PAGE分析外膜孔蛋白oprD2的改变,③泵抑制剂MC20...
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| 关 键 词： | 铜绿假单胞菌 碳青霉烯类 耐药性 碳青霉烯酶 孔蛋白 外排泵 |
Mechanism research of sensitivity to resistance of pseudomonas aeruginosa to carbpenem in the process of treatment using carbpenem |
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| Shen Jilu,Fang Yaping,Xu Yuanhong,et al The First Affiliated Hospital of Anhui Medical University,Hefei ,China.Mechanism research of sensitivity to resistance of pseudomonas aeruginosa to carbpenem in the process of treatment using carbpenem[J].Anhui Medical Journal,2011,32(5):624-629. |
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| Authors: | Shen Jilu Fang Yaping Xu Yuanhong The First Affiliated Hospital of Anhui Medical University Hefei China |
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| Institution: | Shen Jilu,Fang Yaping,Xu Yuanhong,et al The First Affiliated Hospital of Anhui Medical University,Hefei 230032,China |
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| Abstract: | Objective To explore the mechanism of sensitivity to resistance of Pseudomonas aeruginosa to carbpenem in the process of treatment using carbpenem.Methods Two strains Pseudomonas aeruginosa were collected in the process of treatment using carbpenem.Then case was consulted and homology was investigated by PFGE.PorinoprD2 was analyzed by SDS-PAGE.The minimum inhibitory concentrations(MIC) of Imipenem and Meropenem with or without MC207110 were determined by agar dilution method.Expression level of efflux pump... |
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| Keywords: | Pseudomonas aeruginosa Carbpenem Resistance Carbpenemase Porin Efflux pumps |
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