脑出血发病昼夜变化规律与卒中传统危险因素的关系

目的：分析脑出血发病的昼夜变化规律与卒中传统危险因素之间的相关性。方法：前瞻性登记发病时间明确的758例脑出血患者,计算在早上（05：00-10：00）、下午（11：00-16：00）、晚上（17：00-22：00）和夜间（23：00-04：00）发病的频数,行频数分布拟合优度x2检验,检验脑出血发病昼夜变化规律;用多分类Logistic回归分析发病昼夜变化规律与卒中传统危险因素的关系。结果：①早上和晚上是发病的两个高峰,分别占31.0%和35.9%,夜间和下午是两个低谷;年轻（≤60岁）者,晚上是发病最高峰,年老（〉60岁）者早上是发病最高峰;②无论有或无高血压、糖尿病、吸烟、饮酒和卒中史危险因素,脑出血发病昼夜变化规律与总体相一致;③Logistic回归显示,性别、高血压病、糖尿病、吸烟、饮酒史和卒中史与脑出血的发病昼夜变化规律不存在相关性。结论：脑出血的发病呈现早上-晚上双峰分布的昼夜变化规律,年轻者表现为晚高峰优势的特点,年老者表现为早高峰优势的特点,脑出血发病昼夜变化规律与传统卒中危险因素不相关。

Analysis of the relationship between circadian variation of intra cerebral hemorrhage and the traditional risk factors of stroke

Objective: To analysis the relationship between circadian variation of intrac-erebral hemorrhage(ICH) and traditional risk factors of stroke.Methods: Prospective regis-tration of 758 cases with intra-cerebral hemorrhage,whose onset time was confirmed was selected.The cerebral hemorrhage frequency during morning(05:00-10:00),afternoon(11:00-16:00),evening(17:00-22:00) and night(23:00-04:00) and was caleulated and cerebral hemorrhage changes of diurnal variation with the frequency distribution of goodness of ...