| 蛋白激酶C及其亚型对钙通道的调节功能 |
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| 引用本文： | 杨巧林,夏超明.蛋白激酶C及其亚型对钙通道的调节功能[J].国际医学寄生虫病杂志,2009,36(2). |
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| 作者姓名： | 杨巧林 夏超明 |
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| 作者单位： | 苏州大学医学院寄生虫学教研室,215123 |
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| 基金项目： | 卫生部寄生虫病预防与控制技术重点实验室开放课题 |
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| 摘 要： | 吡喹酮是目前治疗血吸虫的惟一特效药,但其作用靶点及机制仍未完全阐明,研究表明吡喹酮的作用靶点町能为钙通道.钙通道可受多种因素的调控,该文综述了蛋白激酶C及其亚型对钙通道的调控作用,为阐明吡喹酮的药物作用机制以及进一步研发抗血吸虫新药提供了思路.
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| 关 键 词： | 蛋白激酶C 钙通道 血吸虫病 |
Regulation of calcium channels by protein kinase C and its subunits |
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| YANG Qiao-lin,XIA Chao-ming.Regulation of calcium channels by protein kinase C and its subunits[J].International JOurnal of Medical Parasitic Diseases,2009,36(2). |
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| Authors: | YANG Qiao-lin XIA Chao-ming |
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| Abstract: | Praziquantel is the only effective drug of choice against schistosomiasis so far,but the mechanism and targets of praziquantel action remain unclear.Studies showed that calcium channel may be the target of praziquantel.Calcium channel can be affected by many factors.This review focused on the regulation of ealeium channels by protein kinase C(PKC)and its subunit. |
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| Keywords: | Protein kinase C Calcium channel Schistosomiasis |
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