依达拉奉治疗一氧化碳中毒后迟发性脑病的疗效观察

目的观察依达拉奉对一氧化碳中毒后迟发性脑病(DEACMP)的疗效,为临床治疗DEACMP提供新思路。方法将2010年2月至2012年10月川北医学院附属医院收治的36例DEACMP患者依据随机数字表法分为依达拉奉组和常规治疗组各18例,两组患者均接受高压氧等常规治疗,依达拉奉组在常规治疗的基础上加用依达拉奉(30 mg依达拉奉加入250 mL生理盐水,静脉滴注,每日2次,持续14 d)。采集患者治疗前后简明精神状态量表评分(MMSE)、经颅彩色多普勒(TCD)、事件相关电位(ERP)、常规脑电图(EEG)、头颅磁共振成像(MRI)等资料对比分析。结果治疗后,依达拉奉组MMSE评分、P300潜伏期及波幅、EEG、头颅MRI的Abaron Peretz分级均优于治疗前,且优于常规治疗组,差异有统计学意义(P<0.05);治疗后,依达拉奉组平均血流速度与治疗前对比差异无统计学意义(P>0.05),与常规治疗组对比差异亦无统计学意义(P>0.05)。结论依达拉奉可改善DEACMP患者的症状,其疗效优于单用高压氧治疗。

Observation on the Efficacy of Edaravone in Treating Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning

Objective To observe the efficacy of edaravone in the treatment for delayed encephalopathy after carbon monoxide poisoning （DEACMP）.Methods A total of 36 cases of patients with DEACMP admitted inNorth Sichuan Medical College Affiliated Hospital from Feb.2010 to Oct.2012 were randomly divided into the control group （routine treatment group） and edaravone group （edarabone treatment group）,with 18 cases in each group.Patients in both groups received hyperbaric oxygen（HBO） treatment,while patients in edaravone group were given extra edaravone（30 mg of edaravone added to 250 mL of normal saline,intravenous infusion,twice a day,for 14 days）.Records of mini-mental state examination （MMSE）,transcranial doppler （TCD）,event-related potential （ERP）,electroencephalogram （EEG）,magnetic resonance imaging（MRI） of the two groups before and after treatments were comparatively analyzed.Results After treatments,the data of MMSE,latent period and amplitude of P300,Abaron Peretz ratings of EEG and MRI of edaravone group were more superior than those before treatment,and also better than the control group,the differences were statistically significant（P ＜0.05）.Whereas there was no statistically significant difference of the TCD data of the two groups （P ＞ 0.05）.Conclusion Edaravone can improve the symptoms of the patients with DEACMP,and the efficacy is better than simple HBO treatment.