| 白细胞介素6启动子区域基因多态与复发性自然流产相关性的研究进展 |
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| 引用本文： | 邱军. 白细胞介素6启动子区域基因多态与复发性自然流产相关性的研究进展[J]. 医学综述, 2014, 20(21): 3862-3865 |
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| 作者姓名： | 邱军 |
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| 作者单位： | 昆明医科大学附属延安医院中心实验室,昆明,650051 |
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| 基金项目： | 云南省科技厅-昆明医学院联合专项，云南省科技厅应用基础研究自筹经费项目 |
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| 摘 要： | 复发性自然流产(RSA)是多基因遗传变异和环境等多重因素共同作用的结果。成功的妊娠依赖于Th1和Th2的免疫平衡,白细胞介素6(IL-6)作为Th2型细胞因子,是维持Th1/Th2平衡的重要因素之一。IL-6基因启动子区-174G/A和-572G/C与IL-6表达水平相关,从而影响流产的发生。该文就IL-6启动子区域基因多态性与RSA的相关性予以综述。
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| 关 键 词： | 复发性自然流产 白细胞介素6 基因多态 |
Research Progress of the Association between the Polymorphism of Interleukin-6 Gene Promoter and Recurrent Spontaneous Abortion |
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| QIU Jun. Research Progress of the Association between the Polymorphism of Interleukin-6 Gene Promoter and Recurrent Spontaneous Abortion[J]. Medical Recapitulate, 2014, 20(21): 3862-3865 |
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| Authors: | QIU Jun |
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| Affiliation: | . ( Central Laboratory, Yah＇an Hospital of Kunming Medical University ,Kunming 650051, China) |
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| Abstract: | Recurrent spontaneous abortion is the result of multiple genes and multiple environment factors. Successful pregnancy depends on Th1 and Th2 immune balance,and as a Th2 type cytokine,IL-6 is one of the important factors for maintaining Th1/Th2 balance. Studies show that the IL-6 promoter region - 174G/C and -572C/G arc associated with IL-6 expression level, which then induces abortion. Here is to make a review of the association between polymorphism of IL-6 promoter region and recurrent spontaneous abortion. |
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| Keywords: | Recurrent spontaneous abortion Interleukin-6 Genetic polymorphism |
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