宿主因素对慢性丙型肝炎抗病毒疗效影响因素的研究进展

丙型病毒性肝炎是由丙型肝炎病毒感染引起的一种以肝脏为主要靶器官的传染性疾病,丙型肝炎易慢性化,导致肝硬化及肝癌,病死率高。聚乙二醇干扰素α联合利巴韦林是目前慢性丙型肝炎(CHC)标准的治疗方案,但按此方案仅50%⁶0%的患者能够获得持续性病毒学应答,提示宿主因素是影响CHC抗病毒疗效的一个重要方面。该文就此进行阐述,从而为临床治疗提供依据。

Research Advances in Host Factors Influence on the Response of Chronic Hepatitis C to Antiviral Therapy

Hepatitis C is an infectious disease caused by hepatitis C virus （HCV）. Liver is the primary target organ. With the development of the disease, it＇s easy to become chronic, finally leading to cirrhosis and liver cell carcinoma （HCC） of high mortality. Currently pegylated interferon-α （PEG-IFN-α） plus ribavirin （RBV） is the standard treatment of chronic hepatitis C （ CHC）, but only 50% to 60% of the patients are able to achieve sustained virological response（ SVR）, indicating that host is an important factor that affect the antiviral efficacy of chronic hepatitis C, which is to be reviewed here, so as to provide evidence for the clinical treatment.