VEGF在糖尿病视网膜病变发病机制中作用的研究新进展

糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病最常见的微血管并发症之一,其基本病理改变是血-视网膜屏障(blood-retinal barrier,BRB)破坏、新生血管形成,后期新生血管膜收缩牵拉引起视网膜脱离。DR的发病机制十分复杂,至今尚未完全阐明。任何病理改变在本质上均是体内动态平衡的失调,新生血管的形成亦然,血管刺激因素增强和(或)抑制因素减少使两者平衡失调即所谓的"血管生成开关"形成。血管内皮生长因子(vascularendothelial growth factor,VEGF)是体内促新生血管形成的主要因子之一,近年来在DR的发病机制以及治疗的研究中广受关注。我们旨在阐述VEGF在DR发病机制中的作用。

Latest progress of VEGF in the pathogenesis of diabetic retinopathy

Diabetic retinopathy is one of the most frequent and the most severe micrangium complications of diabetes mellitus,the fundamental pathology characteristic of DR is breakdown of the blood-retinal barrier and neovascularization.In the later stage of DR,the formation of the epiretinal membrane,which may tractates the retina and produce detachment of the retina,results in progressive deterioration of vision.The pathogenesis is very complex and has not been elucidated completely.Retinal neovascularization results from both increasing of vascular stimulating factor and reducing of vascular inhibiting factor.VEGF,as an important factor promoting angiogenesis,was widely concerned on the pathogenesis of research and treatment of DR recent years.This article aims to explain the effect of VEGF in the pathogenesis of DR.