| 2，4-噻唑二酮的合成 |
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| 引用本文： | 王绍杰,张星一,戚英波. 2，4-噻唑二酮的合成[J]. 中国药物化学杂志, 2000, 10(4): 291-292 |
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| 作者姓名： | 王绍杰 张星一 戚英波 |
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| 作者单位： | 沈阳药科大学制药系!沈阳110015 |
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| 摘 要： | 以硫脲和氯乙酸忆酯为原料，经环合、中和，得到2-亚胺基-4-噻唑酮，然后用20%盐酸水解，合成了目标物2，4-噻唑二酮，总收率为61%，该方法未见文献报道。
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| 关 键 词： | 糖尿病 2 4－噻唑二酮 合成 |
Synthesisof 2,4-Thiazolidinedione |
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| Wang Shaojie,Zhang Xingyi,Qi Yingbo. Synthesisof 2,4-Thiazolidinedione[J]. Chinese Journal of Medicinal Chemistry, 2000, 10(4): 291-292 |
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| Authors: | Wang Shaojie Zhang Xingyi Qi Yingbo |
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| Abstract: | Starting from ethyl chloroacetate and thiourea,via cyclization and neutralization,2 imino 4 thiazolidone was synthesized according to the literature,and then hydrolyzed with 20% hydrochloric acid to give 2,4 thiazolidinedione in an overall yield of 61%.This method was not seen in literature. |
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| Keywords: | diabetes 2 4 thiazolidinedione synthesis |
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