Five newly identified HLA alleles: A*0310, A*2907, B*4435, Cw*0206, Cw*0506, and confirmation of A*3106, B*3924, Cw*0314, DRB1*0322, and DRB1*1433 alleles |
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Authors: | Anholts J D H Drabbels J Verduijn W Oudshoorn M Schreuder G M Th |
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Affiliation: | Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. |
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Abstract: | A number of HLA alleles have been newly identified. This concerns HLA-A*0310, A*2907, B*4435, Cw*0206, Cw*0506, of which Cw*0206 was found in three unrelated individuals, all B*4002 positive. Some other alleles are also presented but confirm earlier detected sequences: A*3106, Cw*0314, DRB1*0322, and DRB1*1433. Moreover, we identified B*3924 in a bone marrow transplant recipient and in five of six unrelated stem cell donors, selected for this patient. In all cases, B*3924 was found on a haplotype combining A*0201, B*3924, Cw*0701, and DRB1*1303. The observation of this extended haplotype is of importance for the selection for stem cell transplantation. Cells expressing B*3924 and B*4435 were typed by serology as B39 and B44, respectively. Cells expressing HLA-A*0310 do not express A3 but type as A-Blank. |
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Keywords: | HLA-A*0310 A*2907 A*3106 B*3924 B*4435 Cw*0206 Cw*0314 Cw*0506 DRB1*0322 DRB1*1433 HLA sequencing HLA serology PCR-SBT |
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