| 丹参素对实验性肝细胞损伤的防护作用 |
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| 引用本文： | 李菁,李跃华.丹参素对实验性肝细胞损伤的防护作用[J].中西医结合肝病杂志,1996,6(3):29-30,32. |
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| 作者姓名： | 李菁 李跃华 |
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| 作者单位： | 南京医科大学 210029
(李菁，李跃华，薛隆翠)，南京医科大学 210029(吴翠贞) |
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| 摘 要： | 在原代培养小鼠肝细胞上用氰化钾缺氧损伤模型，观察不同剂量的氰化钾肝细胞的损伤及丹参素对损伤肝细胞的保护作用，结果表明，氰化钾对肝细胞具有毒性，丹参素能使含２．５ｍｍｏｌ／Ｌ氰化钾肝细胞培养在ＬＤＨ活性明显降低，显著增加肝细胞ＳＯＤ活力，降低ＬＰＯ含量。提示氰化钾所致肝细胞损伤与自由基毒性作用密切相关，丹参素具有稳定细胞膜，清除自由基的作用。
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| 关 键 词： | 丹参素 肝细胞损伤 药理学 肝疾病 |
Protective Effect of Danshensu on Experimental Liver Injury |
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| Li Jing,Li Yuehua . Xue Longcui
Nanjing Medical University.Protective Effect of Danshensu on Experimental Liver Injury[J].Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases,1996,6(3):29-30,32. |
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| Authors: | Li Jing Li Yuehua Xue Longcui
Nanjing Medical University |
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| Abstract: | The model of hypoxic injury with potassium cyanide (KCN) and Danshensu protective effects on KCN-induced damage cell in primary cultures of rat hepatocytes were susceptible to KCN toxicity. Dashensu added to cultrued with 2.5mmol/L KCN caused an obvious decrease of lactic dehydrogenase (LDH) activity and a significant increase in the levels of su-peroxide dismutase (SOD) in comparison with cultured hepatocytes without Danshensu. It suggests that free radicals and lipid peroxidation (LPO) are involved in the causation of KCN-induced cell damage and Danshensu might play an important role in clearing free radicals and preventing cells from being damaged. The obvious protective effects of Danshensu on injury hepatocytes suggest that it might be a prospective pharmacon in clinical treating liver diseases. |
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| Keywords: | Potassium Cyanide Danshensu Hepatocyte Experimental Liver Injury Animal Model |
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