| ENHANCEMENT OF HLA-DR EXPRESSION IN HUMAN HEPATOCELLULAR CARCINOMA WITH INTERFERON |
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| 作者姓名： | 杨连君 隋延仿 陈志南 |
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| 作者单位： | YANG Lianjun;SUI Yan fang;CHEN Zhinan )Department of Pathology，Fourth Military Medical University，Xi 'an 710032) |
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| 基金项目： | 国家自然科学基金，国家高技术研究发展计划(863计划) |
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| 摘 要： | HLA--DRisoneofthemajortypesofhumanmajorhistocompatiblecomplex(MHC)type11molecule.Asamainkilldofsurfaceantigeninhumancells,itplaysanimportantroleintheimmunoreactionandimmunoregulationofthehumanbody.Manystudiesindicatethatinterferon(IFN)canenhancetheHLA-DRexpressionintumorcellsandregulatetheimmunoreactivesituationofthetumor.l]CurrentlythereisnosuchreportthatIFNregulatestheHLADRexpressioninhepatocellularcarcinoma(HCC).TheexpressionofHLA-DRinHCCcellsandnormallivercellsbeforeandafter…
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| 收稿时间： | 21 July 2006 |
| 修稿时间： | 25 August 1999 |
Enhancement of HLA-DR expression in human hepato-cellular carcinoma with interferon |
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| Yang Lianjun,Sui Yanfang,Chen Zhinan.ENHANCEMENT OF HLA-DR EXPRESSION IN HUMAN HEPATOCELLULAR CARCINOMA WITH INTERFERON[J].Chinese Journal of Cancer Research,1999,11(4):241-244. |
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| Authors: | Yang Lianjun Sui Yanfang Chen Zhinan |
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| Institution: | (1) Department of Pathology, Fourth Military Medical University, No. 17, Changle West Road, 710032 Xi'an, China |
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| Abstract: | Objective: To inquire into the regulative effect of interferon (IFN) on HLA-DR expression in human hepatocellular carcinoma
(HCC). Methods: The expression of HLA-DR in 4 kinds of HCC cell lines, HHCC, SMMC-7721, BEL-7402, HCC-9204 and a normal liver
cell line QZG was detected with immunohistochemical ABC and ELISA methods before and after being stimulated by different doses
of IFN-γ or IFN-α. Results: Only a small part of SMMC-7721 cells expressed HLA-DR, and all of the other cell lines were HLA-DR
negative before stimulation with IFN-γ or IFN-α. HLA-DR expression was enhanced in all of the 5 cell lines after stimulation,
and it was correlated with the dose of IFN. QZG cells were less obvious than HCC cells. The effect of IFN-γ was more obvious
than that of IFN-α. Conclusion: IFN can enhance HLA-DR expression in HCC cells.
This work was supported by the National Natural Science Foundation of China (No. 39770827) and National 863 Project of China
(No. 102-09-01-02). |
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| Keywords: | Interferon HLA-DR Hepatocellularcarcinoma Immunohistochemistry ELISA |
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