Immunohistochemical study of annexin V expression in placentae of preeclampsia |
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Authors: | Shu F Sugimura M Kanayama N Kobayashi H Kobayashi T Terao T |
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Affiliation: | Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan. |
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Abstract: | We investigated the clinical significance of annexin V in the placentae with preeclampsia and found: (1) annexin V was detected on trophoblasts in the placentae and the staining intensity of annexin V in the placentae from such patients was reduced when compared to normal placentae; (2) as expression of annexin V was reduced, the gestosis index from patients with preeclampsia was elevated and the standard deviation value in the infant's standard weight was decreased; plasma level of the fibrin degradation products and thrombin-antithrombin III complex from patients were elevated as the expression of anexin V was reduced. These results suggest that the reduced expression of annexin V in the placentae from patients with preeclampsia may lead to a hypercoagulable state in the intervillous space and may be associated with the development of intrauterine growth restriction. |
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