Contact sensitivity to quinidine sulfate from occupational exposure |
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Authors: | Jan E Wahlberg Anders Boman |
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Institution: | Department of Occupational Dermatology, National Board of Occupational Safety and Health and Karolinska Sjukhuset, Stockholm, Sweden |
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Abstract: | Three workers exposed to quinidine sulfate became sensitized after short exposure times (2-3 months). They were patch test positive to quinidine in different vehicles, but negative to the diastereoisomer quinine. Guinea pig maximization tests demonstrated quinidine and quinine to be grade V allergens according to the classification of Magnusson & Kligman. When challenged for cross reactivity, the animals sensitive to quinine did not react to quinidine. Among the quinidine-sensitive guinea pigs, three of 20 (P greater than 0.05) reacted when challenged with quinine. |
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Keywords: | Case reports-contact allergy contact dermatitis cross reactivity guinea pig maximization lest patch testing quinidine sulfate quinine hydrochloride |
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