广州市无偿献血者中抗-HCV阳性人群的比较分析

目的了解广州市不同性别、年龄以及不同职业的无偿献血者抗-HCV阳性率情况。方法对从2000年1月～2010年12月的2 520 179(人)份广州市无偿献血者的血液标本,采用ELISA做抗-HCV双试剂检测并对检测结果做统计学分析。结果广州地区无偿献血者抗-HCV阳性率为0.42%(10 570/2 520 179),且在不同性别、年龄、职业之间差异具有统计学意义(P0.05)。女性抗-HCV阳性率(0.29%)低于男性(0.52%);35岁18～25岁(0.40%);25～35岁(0.36%)]较≥35岁35～45岁(0.54)%,45～55岁(0.52%)]的献血者的抗-HCV阳性率低;工人(0.56%)和无职业者(0.76%)的抗-HCV阳性率比较高,医务人员血样中未检出抗-HCV阳性。结论广州市无偿献血人群中抗-HCV阳性率较低,符合献血条件的≤35岁的人群积极献血将有利于保障临床输血安全;宜加强对工人和无职业者献血安全和输血相关病毒知识的宣传和教育。

Anti-HCV prevalence among volunteer blood donors in Guangzhou,China

Objective To investigate anti-HCV prevalence among volunteer blood donors of different genders,ages and occupations.Methods A total of 2 520 179 blood samples from volunteer blood donors were recruited from January 2000 to December 2010 in Guangzhou.The anti-HCV assays were performed by ELISA,with reagents from two different manufactures.Anti-HCV positivity was defined as positivity on either assay.The results were analyzed statistically.Results Anti-HCV positive rate among volunteer blood donors in Guangzhou was 0.42%(10 570/2 520 179).Significant differences in the positive rates of anti-HCV were found between different ages,genders or professions(P<0.05).Anti-HCV positive rate was lower in women(0.29%) than in men(0.52%).Donors under the age of 35(18~,0.40%;25~,0.36%) presented lower anti-HCV positive rate than those over 35 years of age(35~,0.54%;45~55,0.52%).Higher anti-HCV positivities were observed in workers(0.56%)and unemployed people(0.76%),while none of the medical staff were positive in anti-HCV.Conclusion The anti-HCV prevalent rate was relatively low among volunteer blood donors of Guangzhou.The encouraging people under 35 years to donate blood could improve blood safety.It is of importance to improve propaganda and education to the workers and unemployed individuals on blood donation safety and transfusion-related infectious diseases.